Post by flounder on Jul 31, 2014 9:46:56 GMT -5
7/30/2014
Pennsylvania Helps State and National Researchers Combat Chronic Wasting Disease
News for Immediate Release
July 30, 2014
Harrisburg – Seven deer testing positive for Chronic Wasting Disease are providing researchers with valuable samples and insights on combating the deadly disease.
The deer from an infected Reynoldsville, Jefferson County farm tested positive for Chronic Wasting Disease. Two other white-tailed deer died in April on the farm and tested positive for the disease. This marks the 14th white-tailed deer in the state to test positive for the disease since 2012.
“Chronic Wasting Disease is making its way across the state and we’re doing everything we can to stop its spread,” said Agriculture Secretary George Greig. “By working with the Pennsylvania Game Commission, state and national deer farmers associations and researchers from across the nation, we can better combat the disease.”
The department set out to provide as much information as possible to aid researchers to develop better diagnostic methods. It granted permission for researchers from Kansas State University, in cooperation with state and national deer farming associations, to take samples from the live deer. The samples are being used to study potential live-animal diagnostic tests to detect the disease.
Postmortem samples were distributed to United States Department of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS), Veterinary and Wildlife Services and USDA Agricultural Research Services for additional research about the disease.
“This is an unprecedented level of infection in a captive deer herd,” said Greig. “The department and deer farmers worked together to accommodate the requests of these researchers. The more we know, the greater the chance we can eradicate the disease.”
An investigation continues into any other deer farms that may have purchased or supplied the Reynoldsville herd with deer. Additional herds may be quarantined.
Chronic Wasting Disease attacks the brains of infected antlered animals such as deer, elk and moose, producing small lesions that eventually result in death. Animals can get the disease through direct contact with saliva, feces and urine from an infected animal.
There is no evidence that humans or livestock can get the disease, according to the Centers for Disease Control and Prevention.
Symptoms include weight loss, excessive salivation, increased drinking and urination, and abnormal behavior like stumbling, trembling and depression. Infected deer and elk may also allow unusually close approach by humans or natural predators. The disease is fatal and there is no known treatment or vaccine.
Two Adams County deer tested positive for Chronic Wasting Disease in 2012. During the investigation the department quarantined 27 farms in 16 counties associated with the positive samples. Since then, five farms remain quarantined.
Surveillance for the disease has been ongoing in Pennsylvania since 1998.
The Department of Agriculture coordinates a mandatory surveillance program for more than 23,000 captive deer on 1,100 breeding farms, hobby farms and shooting preserves.
The Pennsylvania Game Commission collects samples from hunter-harvested deer and elk and those that appear sick or behave abnormally. Since 1998, the commission has tested more than 38,000 free-ranging deer and elk for the disease. Five wild deer have tested positive for the disease since 2013.
For more information, visit www.agriculture.state.pa.us and click on the “Chronic Wasting Disease Information” button.
Media contact: Samantha Elliott Krepps, 717-787-5085
###
www.pa.gov/Pages/NewsDetails.aspx?agency=Agriculture&item=15882#.U9pRAcJ0yt8
Monday, July 28, 2014
*** Mitigating the Risk of Transmission and Environmental Contamination of Transmissible Spongiform Encephalopathies 2013 Annual Report
transmissiblespongiformencephalopathy.blogspot.com/2014/07/mitigating-risk-of-transmission-and.html
PRION 2014 CONFERENCE
CHRONIC WASTING DISEASE CWD
A FEW FINDINGS ;
Conclusions. To our knowledge, this is the first established experimental model of CWD in TgSB3985. We found evidence for co-existence or divergence of two CWD strains adapted to Tga20 mice and their replication in TgSB3985 mice. Finally, we observed phenotypic differences between cervid-derived CWD and CWD/Tg20 strains upon propagation in TgSB3985 mice. Further studies are underway to characterize these strains.
We conclude that TSE infectivity is likely to survive burial for long time periods with minimal loss of infectivity and limited movement from the original burial site. However PMCA results have shown that there is the potential for rainwater to elute TSE related material from soil which could lead to the contamination of a wider area. These experiments reinforce the importance of risk assessment when disposing of TSE risk materials.
The results show that even highly diluted PrPSc can bind efficiently to polypropylene, stainless steel, glass, wood and stone and propagate the conversion of normal prion protein. For in vivo experiments, hamsters were ic injected with implants incubated in 1% 263K-infected brain homogenate. Hamsters, inoculated with 263K-contaminated implants of all groups, developed typical signs of prion disease, whereas control animals inoculated with non-contaminated materials did not.
Our data establish that meadow voles are permissive to CWD via peripheral exposure route, suggesting they could serve as an environmental reservoir for CWD. Additionally, our data are consistent with the hypothesis that at least two strains of CWD circulate in naturally-infected cervid populations and provide evidence that meadow voles are a useful tool for CWD strain typing.
Conclusion. CWD prions are shed in saliva and urine of infected deer as early as 3 months post infection and throughout the subsequent >1.5 year course of infection. In current work we are examining the relationship of prionemia to excretion and the impact of excreted prion binding to surfaces and particulates in the environment.
Conclusion. CWD prions (as inferred by prion seeding activity by RT-QuIC) are shed in urine of infected deer as early as 6 months post inoculation and throughout the subsequent disease course. Further studies are in progress refining the real-time urinary prion assay sensitivity and we are examining more closely the excretion time frame, magnitude, and sample variables in relationship to inoculation route and prionemia in naturally and experimentally CWD-infected cervids.
Conclusions. Our results suggested that the odds of infection for CWD is likely controlled by areas that congregate deer thus increasing direct transmission (deer-to-deer interactions) or indirect transmission (deer-to-environment) by sharing or depositing infectious prion proteins in these preferred habitats. Epidemiology of CWD in the eastern U.S. is likely controlled by separate factors than found in the Midwestern and endemic areas for CWD and can assist in performing more efficient surveillance efforts for the region.
Conclusions. During the pre-symptomatic stage of CWD infection and throughout the course of disease deer may be shedding multiple LD50 doses per day in their saliva. CWD prion shedding through saliva and excreta may account for the unprecedented spread of this prion disease in nature.
see full text and more ;
Monday, June 23, 2014
*** PRION 2014 CHRONIC WASTING DISEASE CWD
chronic-wasting-disease.blogspot.com/2014/06/prion-2014-chronic-wasting-disease-cwd.html
Thursday, July 03, 2014
*** How Chronic Wasting Disease is affecting deer population and what’s the risk to humans and pets?
chronic-wasting-disease.blogspot.com/2014/07/how-chronic-wasting-disease-is.html
Tuesday, July 01, 2014
*** CHRONIC WASTING DISEASE CWD TSE PRION DISEASE, GAME FARMS, AND POTENTIAL RISK FACTORS THERE FROM
chronic-wasting-disease.blogspot.com/2014/07/chronic-wasting-disease-cwd-tse-prion.html
Sunday, July 13, 2014
Louisiana deer mystery unleashes litigation 6 does still missing from CWD index herd in Pennsylvania Great Escape
chronic-wasting-disease.blogspot.com/2014/07/louisiana-deer-mystery-unleashes.html
Wednesday, November 14, 2012
PENNSYLVANIA 2012 THE GREAT ESCAPE OF CWD INVESTIGATION MOVES INTO LOUISIANA and INDIANA
chronic-wasting-disease.blogspot.com/2012/11/pennsylvania-2012-great-escape-of-cwd_14.html
Tuesday, October 23, 2012
PA Captive deer from CWD-positive farm roaming free
chronic-wasting-disease.blogspot.com/2012/10/pa-captive-deer-from-cwd-positive-farm.html
Tuesday, May 28, 2013
Chronic Wasting Disease CWD quarantine Louisiana via CWD index herd Pennsylvania Update May 28, 2013
*** 6 doe from Pennsylvania CWD index herd still on the loose in Louisiana, quarantine began on October 18, 2012, still ongoing, Lake Charles premises.
chronic-wasting-disease.blogspot.com/2013/05/chronic-wasting-disease-cwd-quarantine.html
Saturday, June 29, 2013
*** PENNSYLVANIA CAPTIVE CWD INDEX HERD MATE YELLOW *47 STILL RUNNING LOOSE IN INDIANA, YELLOW NUMBER 2 STILL MISSING, AND OTHERS ON THE RUN STILL IN LOUISIANA
chronic-wasting-disease.blogspot.com/2013/06/pennsylvania-captive-cwd-index-herd.html
Tuesday, June 11, 2013
*** CWD GONE WILD, More cervid escapees from more shooting pens on the loose in Pennsylvania
chronic-wasting-disease.blogspot.com/2013/06/cwd-gone-wild-more-cervid-escapees-from.html
Sunday, January 06, 2013
USDA TO PGC ONCE CAPTIVES ESCAPE
*** "it‘s no longer its business.”
chronic-wasting-disease.blogspot.com/2013/01/usda-to-pgc-once-captives-escape-its-no.html
”The occurrence of CWD must be viewed against the contest of the locations in which it occurred. It was an incidental and unwelcome complication of the respective wildlife research programmes. Despite it’s subsequent recognition as a new disease of cervids, therefore justifying direct investigation, no specific research funding was forthcoming. The USDA veiwed it as a wildlife problem and consequently not their province!” ...page 26.
collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
Thursday, July 31, 2014
Pennsylvania Helps State and National Researchers Combat Chronic Wasting Disease
chronic-wasting-disease.blogspot.com/2014/07/pennsylvania-helps-state-and-national.html
Pennsylvania Helps State and National Researchers Combat Chronic Wasting Disease
News for Immediate Release
July 30, 2014
Harrisburg – Seven deer testing positive for Chronic Wasting Disease are providing researchers with valuable samples and insights on combating the deadly disease.
The deer from an infected Reynoldsville, Jefferson County farm tested positive for Chronic Wasting Disease. Two other white-tailed deer died in April on the farm and tested positive for the disease. This marks the 14th white-tailed deer in the state to test positive for the disease since 2012.
“Chronic Wasting Disease is making its way across the state and we’re doing everything we can to stop its spread,” said Agriculture Secretary George Greig. “By working with the Pennsylvania Game Commission, state and national deer farmers associations and researchers from across the nation, we can better combat the disease.”
The department set out to provide as much information as possible to aid researchers to develop better diagnostic methods. It granted permission for researchers from Kansas State University, in cooperation with state and national deer farming associations, to take samples from the live deer. The samples are being used to study potential live-animal diagnostic tests to detect the disease.
Postmortem samples were distributed to United States Department of Agriculture (USDA), Animal and Plant Health Inspection Service (APHIS), Veterinary and Wildlife Services and USDA Agricultural Research Services for additional research about the disease.
“This is an unprecedented level of infection in a captive deer herd,” said Greig. “The department and deer farmers worked together to accommodate the requests of these researchers. The more we know, the greater the chance we can eradicate the disease.”
An investigation continues into any other deer farms that may have purchased or supplied the Reynoldsville herd with deer. Additional herds may be quarantined.
Chronic Wasting Disease attacks the brains of infected antlered animals such as deer, elk and moose, producing small lesions that eventually result in death. Animals can get the disease through direct contact with saliva, feces and urine from an infected animal.
There is no evidence that humans or livestock can get the disease, according to the Centers for Disease Control and Prevention.
Symptoms include weight loss, excessive salivation, increased drinking and urination, and abnormal behavior like stumbling, trembling and depression. Infected deer and elk may also allow unusually close approach by humans or natural predators. The disease is fatal and there is no known treatment or vaccine.
Two Adams County deer tested positive for Chronic Wasting Disease in 2012. During the investigation the department quarantined 27 farms in 16 counties associated with the positive samples. Since then, five farms remain quarantined.
Surveillance for the disease has been ongoing in Pennsylvania since 1998.
The Department of Agriculture coordinates a mandatory surveillance program for more than 23,000 captive deer on 1,100 breeding farms, hobby farms and shooting preserves.
The Pennsylvania Game Commission collects samples from hunter-harvested deer and elk and those that appear sick or behave abnormally. Since 1998, the commission has tested more than 38,000 free-ranging deer and elk for the disease. Five wild deer have tested positive for the disease since 2013.
For more information, visit www.agriculture.state.pa.us and click on the “Chronic Wasting Disease Information” button.
Media contact: Samantha Elliott Krepps, 717-787-5085
###
www.pa.gov/Pages/NewsDetails.aspx?agency=Agriculture&item=15882#.U9pRAcJ0yt8
Monday, July 28, 2014
*** Mitigating the Risk of Transmission and Environmental Contamination of Transmissible Spongiform Encephalopathies 2013 Annual Report
transmissiblespongiformencephalopathy.blogspot.com/2014/07/mitigating-risk-of-transmission-and.html
PRION 2014 CONFERENCE
CHRONIC WASTING DISEASE CWD
A FEW FINDINGS ;
Conclusions. To our knowledge, this is the first established experimental model of CWD in TgSB3985. We found evidence for co-existence or divergence of two CWD strains adapted to Tga20 mice and their replication in TgSB3985 mice. Finally, we observed phenotypic differences between cervid-derived CWD and CWD/Tg20 strains upon propagation in TgSB3985 mice. Further studies are underway to characterize these strains.
We conclude that TSE infectivity is likely to survive burial for long time periods with minimal loss of infectivity and limited movement from the original burial site. However PMCA results have shown that there is the potential for rainwater to elute TSE related material from soil which could lead to the contamination of a wider area. These experiments reinforce the importance of risk assessment when disposing of TSE risk materials.
The results show that even highly diluted PrPSc can bind efficiently to polypropylene, stainless steel, glass, wood and stone and propagate the conversion of normal prion protein. For in vivo experiments, hamsters were ic injected with implants incubated in 1% 263K-infected brain homogenate. Hamsters, inoculated with 263K-contaminated implants of all groups, developed typical signs of prion disease, whereas control animals inoculated with non-contaminated materials did not.
Our data establish that meadow voles are permissive to CWD via peripheral exposure route, suggesting they could serve as an environmental reservoir for CWD. Additionally, our data are consistent with the hypothesis that at least two strains of CWD circulate in naturally-infected cervid populations and provide evidence that meadow voles are a useful tool for CWD strain typing.
Conclusion. CWD prions are shed in saliva and urine of infected deer as early as 3 months post infection and throughout the subsequent >1.5 year course of infection. In current work we are examining the relationship of prionemia to excretion and the impact of excreted prion binding to surfaces and particulates in the environment.
Conclusion. CWD prions (as inferred by prion seeding activity by RT-QuIC) are shed in urine of infected deer as early as 6 months post inoculation and throughout the subsequent disease course. Further studies are in progress refining the real-time urinary prion assay sensitivity and we are examining more closely the excretion time frame, magnitude, and sample variables in relationship to inoculation route and prionemia in naturally and experimentally CWD-infected cervids.
Conclusions. Our results suggested that the odds of infection for CWD is likely controlled by areas that congregate deer thus increasing direct transmission (deer-to-deer interactions) or indirect transmission (deer-to-environment) by sharing or depositing infectious prion proteins in these preferred habitats. Epidemiology of CWD in the eastern U.S. is likely controlled by separate factors than found in the Midwestern and endemic areas for CWD and can assist in performing more efficient surveillance efforts for the region.
Conclusions. During the pre-symptomatic stage of CWD infection and throughout the course of disease deer may be shedding multiple LD50 doses per day in their saliva. CWD prion shedding through saliva and excreta may account for the unprecedented spread of this prion disease in nature.
see full text and more ;
Monday, June 23, 2014
*** PRION 2014 CHRONIC WASTING DISEASE CWD
chronic-wasting-disease.blogspot.com/2014/06/prion-2014-chronic-wasting-disease-cwd.html
Thursday, July 03, 2014
*** How Chronic Wasting Disease is affecting deer population and what’s the risk to humans and pets?
chronic-wasting-disease.blogspot.com/2014/07/how-chronic-wasting-disease-is.html
Tuesday, July 01, 2014
*** CHRONIC WASTING DISEASE CWD TSE PRION DISEASE, GAME FARMS, AND POTENTIAL RISK FACTORS THERE FROM
chronic-wasting-disease.blogspot.com/2014/07/chronic-wasting-disease-cwd-tse-prion.html
Sunday, July 13, 2014
Louisiana deer mystery unleashes litigation 6 does still missing from CWD index herd in Pennsylvania Great Escape
chronic-wasting-disease.blogspot.com/2014/07/louisiana-deer-mystery-unleashes.html
Wednesday, November 14, 2012
PENNSYLVANIA 2012 THE GREAT ESCAPE OF CWD INVESTIGATION MOVES INTO LOUISIANA and INDIANA
chronic-wasting-disease.blogspot.com/2012/11/pennsylvania-2012-great-escape-of-cwd_14.html
Tuesday, October 23, 2012
PA Captive deer from CWD-positive farm roaming free
chronic-wasting-disease.blogspot.com/2012/10/pa-captive-deer-from-cwd-positive-farm.html
Tuesday, May 28, 2013
Chronic Wasting Disease CWD quarantine Louisiana via CWD index herd Pennsylvania Update May 28, 2013
*** 6 doe from Pennsylvania CWD index herd still on the loose in Louisiana, quarantine began on October 18, 2012, still ongoing, Lake Charles premises.
chronic-wasting-disease.blogspot.com/2013/05/chronic-wasting-disease-cwd-quarantine.html
Saturday, June 29, 2013
*** PENNSYLVANIA CAPTIVE CWD INDEX HERD MATE YELLOW *47 STILL RUNNING LOOSE IN INDIANA, YELLOW NUMBER 2 STILL MISSING, AND OTHERS ON THE RUN STILL IN LOUISIANA
chronic-wasting-disease.blogspot.com/2013/06/pennsylvania-captive-cwd-index-herd.html
Tuesday, June 11, 2013
*** CWD GONE WILD, More cervid escapees from more shooting pens on the loose in Pennsylvania
chronic-wasting-disease.blogspot.com/2013/06/cwd-gone-wild-more-cervid-escapees-from.html
Sunday, January 06, 2013
USDA TO PGC ONCE CAPTIVES ESCAPE
*** "it‘s no longer its business.”
chronic-wasting-disease.blogspot.com/2013/01/usda-to-pgc-once-captives-escape-its-no.html
”The occurrence of CWD must be viewed against the contest of the locations in which it occurred. It was an incidental and unwelcome complication of the respective wildlife research programmes. Despite it’s subsequent recognition as a new disease of cervids, therefore justifying direct investigation, no specific research funding was forthcoming. The USDA veiwed it as a wildlife problem and consequently not their province!” ...page 26.
collections.europarchive.org/tna/20080102193705/http://www.bseinquiry.gov.uk/files/mb/m11b/tab01.pdf
Thursday, July 31, 2014
Pennsylvania Helps State and National Researchers Combat Chronic Wasting Disease
chronic-wasting-disease.blogspot.com/2014/07/pennsylvania-helps-state-and-national.html