I don't have the words.....
i do. stupid and irresponsible.
GAME FARMERS, CWD, AND THEIR COMMENTS...disturbing...frightening even. it seems they are oblivious to their own demise. ...
see comments ;
www.regulations.gov/#!docketDetail;rpp=250;so=ASC;sb=postedDate;po=300;D=APHIS-2006-0118
CWD has been identified in free-ranging cervids in 15 US states and 2 Canadian provinces and in ≈ 100 captive herds in 15 states and provinces and in South Korea (Figure 1, panel B). SNIP... Long-term effects of CWD on cervid populations and ecosystems remain unclear as the disease continues to spread and prevalence increases. In captive herds, CWD might persist at high levels and lead to complete herd destruction in the absence of human culling. Epidemiologic modeling suggests the disease could have severe effects on free-ranging deer populations, depending on hunting policies and environmental persistence (8,9). CWD has been associated with large decreases in free-ranging mule deer populations in an area of high CWD prevalence (Boulder, Colorado, USA) (5).
PLEASE STUDY THIS MAP, COMPARE FARMED CWD TO WILD CWD...TSS
wwwnc.cdc.gov/eid/article/18/3/11-0685-f1.htm Saturday, February 18, 2012
Occurrence, Transmission, and Zoonotic Potential of Chronic Wasting Disease
CDC Volume 18, Number 3—March 2012
CWD has been identified in free-ranging cervids in 15 US states and 2 Canadian provinces and in ≈100 captive herds in 15 states and provinces and in South Korea (Figure 1, panel B).
wwwnc.cdc.gov/eid/article/18/3/11-0685_article.htm Thursday, February 09, 2012
50 GAME FARMS IN USA INFECTED WITH CHRONIC WASTING DISEASE
chronic-wasting-disease.blogspot.com/2012/02/50-game-farms-to-date-in-usa-infected.html how many states have $465,000., and can quarantine there from of each cwd said infected farm, but how many states can afford this for all the cwd infected cervid game ranch type farms
i think each one of these game farms should have insurance to cover for the state and it's wild herds, when these escapees, escape into the wild, and or when these game farms become exposed and infected.
Tuesday, December 20, 2011
CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) Farm Update DECEMBER 2011
The CWD infection rate was nearly 80%, the highest ever in a North American captive herd.
RECOMMENDATION: That the Board approve the purchase of 80 acres of land for $465,000 for the Statewide Wildlife Habitat Program in Portage County and approve the restrictions on public use of the site.
snip...see full text and much more here ;
THE states are going to have to regulate how many farms that are allowed, or every state in the USA will wind up being just one big private fenced in game farm.
kind of like they did with the shrimping industry in the bays, when there got to be too many shrimp boats, you stop issuing permits, and then lower the exist number of permits, by not renewing them, due to reduced permits issued.
how many states have $465,000., and can quarantine and purchase there from, each cwd said infected farm, but how many states can afford this for all the cwd infected cervid game ranch type farms
11,000 game farms X $465,000., do all these game farms have insurance to pay for this risk of infected the wild cervid herds, in each state
Tuesday, December 20, 2011
CHRONIC WASTING DISEASE CWD WISCONSIN Almond Deer (Buckhorn Flats) Farm Update DECEMBER 2011
The CWD infection rate was nearly 80%, the highest ever in a North American captive herd.
RECOMMENDATION: That the Board approve the purchase of 80 acres of land for $465,000 for the Statewide Wildlife Habitat Program in Portage County and approve the restrictions on public use of the site.
Form 1100-001
(R 2/11)
NATURAL RESOURCES BOARD AGENDA ITEM
SUBJECT: Information Item: Almond Deer Farm Update
FOR: DECEMBER 2011 BOARD MEETING
TUESDAY
TO BE PRESENTED BY TITLE: Tami Ryan, Wildlife Health Section Chief
SUMMARY:
dnr.wi.gov/about/nrb/2011/december/12-11-2b2.pdf chronic-wasting-disease.blogspot.com/2011/12/chronic-wasting-disease-cwd-wisconsin.html 2010 WISCONSIN CAPTIVE DEER ESCAPES
> There were 26 reported escape incidents so far this year, this amounted to 20 actual confirmed escape incidents because 3 were previously reported, 2 were confirmed as wild deer, and 1 incident was not confirmed.
Wisconsin Conservation Congress CWD Committee Notes recorded by Secretary- Tony Grabski, Iowa County Delegate From the meeting at Mead Wildlife Area Visitor Center Milladore, WI Saturday, August 7, 2010, 9:30 AM
C. & D. Captive Cervid and Law Enforcement Update (11:10 AM)- Warden Pete Dunn gave the captive cervid farm update. There were 26 reported escape incidents so far this year, this amounted to 20 actual confirmed escape incidents because 3 were previously reported, 2 were confirmed as wild deer, and 1 incident was not confirmed. Approximately 30% of these escapes were caused by gates being left open and the other 70% resulted from bad fencing or fence related issues. The 20 actual confirmed escape incidents amounted to 77 total animals. 50 of the escaped animals were recovered or killed and 27 were not recovered and remain unaccounted for. Last year the CWD Committee passed a resolution to require double gates, but this has not gone into effect yet. Questions were raised by the committee about double fencing requirements? Pete responded that double fencing has not been practical or accepted by the industry. The DNR has the authority to do fence inspections. ?If a fence fails to pass the inspection the fencing certificate can be revoked and the farmer can be issued a citation. This year three citations and one warning have been issued for escapes.
dnr.wi.gov/org/nrboard/congress/minutes/2010/cwd_committee_2010.pdf Monday, January 16, 2012
9 GAME FARMS IN WISCONSIN TEST POSITIVE FOR CWD
chronic-wasting-disease.blogspot.com/2012/01/9-game-farms-in-wisconsin-test-positive.html Friday, February 03, 2012
Wisconsin Farm-Raised Deer Farms and CWD there from 2012 report Singeltary et al
chronic-wasting-disease.blogspot.com/2012/02/wisconsin-farm-raised-deer-farms-and.html Deer, elk continue to escape from state farms
Article by: DOUG SMITH , Star Tribune Updated: March 14, 2011 - 12:08 PM
Curbing chronic wasting disease remains a concern; officials are increasing enforcement.
Almost 500 captive deer and elk have escaped from Minnesota farms over the past five years, and 134 were never recaptured or killed.
So far this year, 17 deer have escaped, and officials are still searching for many of those.
see ;
Friday, September 28, 2012
Stray elk renews concerns about deer farm security Minnesota
chronic-wasting-disease.blogspot.com/2012/09/stray-elk-renews-concerns-about-deer.html Monday, June 11, 2012
OHIO Captive deer escapees and non-reporting
chronic-wasting-disease.blogspot.com/2012/06/ohio-captive-deer-escapees-and-non.html Wednesday, January 07, 2009
CWD to tighten taxidermy rules Hunters need to understand regulations
chronic-wasting-disease.blogspot.com/2009/01/cwd-to-tighten-taxidermy-rules-hunters.html CWD, GAME FARMS, BAITING, AND POLITICS
chronic-wasting-disease.blogspot.com/2009/01/cwd-game-farms-baiting-and-politics.html chronic-wasting-disease.blogspot.com/2008/08/cwd-feeding-and-baiting-piles.html Monday, September 17, 2012
Rapid Transepithelial Transport of Prions Following Inhalation
transmissiblespongiformencephalopathy.blogspot.com/2012/09/rapid-transepithelial-transport-of.html Thursday, December 29, 2011
Aerosols An underestimated vehicle for transmission of prion diseases?
PRION
www.landesbioscience.com please see more on Aerosols and TSE prion disease here ;
transmissiblespongiformencephalopathy.blogspot.com/2011/12/aerosols-underestimated-vehicle-for.html my proposal for cervid game farms. ...
Friday, October 12, 2012
Texas Animal Health Commission (TAHC) is Now Accepting Comments on Rule Proposals for “Chronic Wasting Disease (CWD)”
TO: comments@tahc.state.tx.us;
Texas Animal Health Commission (TAHC)
chronic-wasting-disease.blogspot.com/2012/10/texas-animal-health-commission-tahc-is.html what about urine attactants and CWD
Research Paper
Salivary prions in sheep and deer
Volume 6, Issue 1 January/February/March 2012
Pages 52 – 61
dx.doi.org/10.4161/pri.6.1.16984 Gültekin Tamgüney, Jürgen A. Richt, Amir N. Hamir, Justin J. Greenlee, Michael W. Miller, Lisa L. Wolfe, Tracey M. Sirochman, Alan J. Young, David V. Glidden, Natrina L. Johnson, Kurt Giles, Stephen J. DeArmond and Stanley B. Prusiner
Gültekin Tamgüney Institute for Neurodegenerative Diseases; Department of Neurology; University of California, San Francisco, CA USA Jürgen A. Richt National Animal Disease Center, ARS-USDA; Ames, IA USA Amir N. Hamir National Animal Disease Center, ARS-USDA; Ames, IA USA Justin J. Greenlee National Animal Disease Center, ARS-USDA; Ames, IA USA Michael W. Miller Colorado Division of Wildlife, Wildlife Research Center; Fort Collins, CO USA Lisa L. Wolfe Colorado Division of Wildlife, Wildlife Research Center; Fort Collins, CO USA Tracey M. Sirochman Colorado Division of Wildlife, Wildlife Research Center; Fort Collins, CO USA Alan J. Young Department of Veterinary Science, South Dakota State University; Brookings, SD USA David V. Glidden Departments of Epidemiology and Biostatistics; University of California, San Francisco, CA USA Natrina L. Johnson Institute for Neurodegenerative Diseases; San Francisco, CA USA Kurt Giles Institute for Neurodegenerative Diseases; Department of Neurology; University of California, San Francisco, CA USA Stephen J. DeArmond Institute for Neurodegenerative Diseases; San Francisco, CA USA; Department of Pathology, University of California; San Francisco, CA USA Stanley B. Prusiner Corresponding author: stanley@ind.ucsf.edu Institute for Neurodegenerative Diseases; Department of Neurology; University of California, San Francisco, CA USA
Scrapie of sheep and chronic wasting disease (CWD) of cervids are transmissible prion diseases. Milk and placenta have been identified as sources of scrapie prions but do not explain horizontal transmission. In contrast, CWD prions have been reported in saliva, urine and feces, which are thought to be responsible for horizontal transmission. While the titers of CWD prions have been measured in feces, levels in saliva or urine are unknown. Because sheep produce ~17 L/day of saliva, and scrapie prions are present in tongue and salivary glands of infected sheep, we asked if scrapie prions are shed in saliva. We inoculated transgenic (Tg) mice expressing ovine prion protein, Tg(OvPrP) mice, with saliva from seven Cheviot sheep with scrapie. Six of seven samples transmitted prions to Tg(OvPrP) mice with titers of -0.5 to 1.7 log ID50 U/ml. Similarly, inoculation of saliva samples from two mule deer with CWD transmitted prions to Tg(ElkPrP) mice with titers of -1.1 to -0.4 log ID50 U/ml. Assuming similar shedding kinetics for salivary prions as those for fecal prions of deer, we estimated the secreted salivary prion dose over a 10-mo period to be as high as 8.4 log ID50 units for sheep and 7.0 log ID50 units for deer. These estimates are similar to 7.9 log ID50 units of fecal CWD prions for deer. Because saliva is mostly swallowed, salivary prions may reinfect tissues of the gastrointestinal tract and contribute to fecal prion shedding. Salivary prions shed into the environment provide an additional mechanism for horizontal prion transmission.
www.landesbioscience.com/journals/prion/article/16984/ ALSO, NOTE MINERAL LICKS A POSSIBLE SOURCE AND TRANSMISSION MODE FOR CWD
chronic-wasting-disease.blogspot.com/2009/08/third-international-cwd-symposium-july.html Elk and Deer Use of Mineral Licks: Implications for Disease Transmission
Kurt C. VerCauteren1*, Michael J. Lavelle1, Gregory E. Phillips1, Justin W. Fischer1, and Randal S. Stahl1 1United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services, National Wildlife Research Center, 4101 LaPorte Avenue, Fort Collins, CO 80521-2154, USA *Cooresponding author e-mail: kurt.c.vercauteren@aphis.usda.gov
North American cervids require and actively seek out minerals to satisfy physiological requirements. Minerals required by free-ranging cervids exist within natural and artificial mineral licks that commonly serve as focal sites for cervids. Ingestion of soils contaminated with the agent that causes chronic wasting disease (CWD) may result in risk of contracting CWD. Our objective was to evaluate the extent and nature of use of mineral licks by CWD-susceptible cervid species. We used animal-activated cameras to monitor use of 18 mineral licks between 1 June and 16 October 2006 in Rocky Mountain National Park, north-central Colorado. We also assessed mineral concentrations at mineral licks to evaluate correlations between visitation rates and site-specific characteristics. We collected > 400,000 images of which 991 included elk, 293 included deer, and 6 included moose. We documented elk and deer participating in a variety of potentially risky behaviors (e.g., ingesting soil, ingesting water, defecating, urinating) while at mineral licks. Results from the mineral analyses combined with camera data revealed that visitation was highest at sodium-rich mineral licks. Mineral licks may play a role in disease transmission by acting as sites of increased interaction as well as reservoirs for deposition, accumulation, and ingestion of disease agents.
www.cwd-info.org/pdf/3rd_CWD_Symposium_utah.pdf chronic-wasting-disease.blogspot.com/2009/08/third-international-cwd-symposium-july.html PO-081: Chronic wasting disease in the cat— Similarities to feline spongiform encephalopathy (FSE)
www.landesbioscience.com/journals/prion/04-Prion6-2-Pathogenesis-and-pathology.pdf chronic-wasting-disease.blogspot.com/2012/05/chronic-wasting-disease-cwd-prion2012.html www.prion2011.ca/files/PRION_2011_-_Posters_(May_5-11).pdf felinespongiformencephalopathyfse.blogspot.com/2011/08/susceptibility-of-domestic-cats-to-cwd.html Thursday, May 31, 2012
CHRONIC WASTING DISEASE CWD PRION2012 Aerosol, Inhalation transmission, Scrapie, cats, species barrier, burial, and more
chronic-wasting-disease.blogspot.com/2012/05/chronic-wasting-disease-cwd-prion2012.html UPDATED DATA ON 2ND CWD STRAIN Wednesday, September 08, 2010 CWD PRION CONGRESS SEPTEMBER 8-11 2010
chronic-wasting-disease.blogspot.com/2010/09/cwd-prion-2010.html Tuesday, January 10, 2012
ESHRE position statement concerning prion detection in urinary gonadotropin formulations
transmissiblespongiformencephalopathy.blogspot.com/2012/01/eshre-position-statement-concerning.html Prion Disease Detection, PMCA Kinetics, and IgG in Urine from Sheep Naturally/Experimentally Infected with Scrapie and Deer with Preclinical/Clinical Chronic Wasting Disease
▿Richard Rubenstein1,*, Binggong Chang1, Perry Gray2, Martin Piltch2, Marie S. Bulgin3, Sharon Sorensen-Melson3 and Michael W. Miller4 + Author Affiliations
1Departments of Neurology and Physiology/Pharmacology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, New York 11203 2Los Alamos National Laboratory, Los Alamos, New Mexico 87545 3University of Idaho, Caine Veterinary Teaching and Research Center, 1020 E. Homedale Road, Caldwell, Idaho 83607 4Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Colorado 80526-2097
ABSTRACT
Prion diseases, also known as transmissible spongiform encephalopathies, are fatal neurodegenerative disorders. Low levels of infectious agent and limited, infrequent success of disease transmissibility and PrPSc detection have been reported with urine from experimentally infected clinical cervids and rodents. We report the detection of prion disease-associated seeding activity (PASA) in urine from naturally and orally infected sheep with clinical scrapie agent and orally infected preclinical and infected white-tailed deer with clinical chronic wasting disease (CWD). This is the first report on PASA detection of PrPSc from the urine of naturally or preclinical prion-diseased ovine or cervids. Detection was achieved by using the surround optical fiber immunoassay (SOFIA) to measure the products of limited serial protein misfolding cyclic amplification (sPMCA). Conversion of PrPC to PrPSc was not influenced by the presence of poly(A) during sPMCA or by the homogeneity of the PrP genotypes between the PrPC source and urine donor animals. Analysis of the sPMCA-SOFIA data resembled a linear, rather than an exponential, course. Compared to uninfected animals, there was a 2- to 4-log increase of proteinase K-sensitive, light chain immunoglobulin G (IgG) fragments in scrapie-infected sheep but not in infected CWD-infected deer. The higher-than-normal range of IgG levels found in the naturally and experimentally infected clinical scrapie-infected sheep were independent of their genotypes. Although analysis of urine samples throughout the course of infection would be necessary to determine the usefulness of altered IgG levels as a disease biomarker, detection of PrPSc from PASA in urine points to its potential value for antemortem diagnosis of prion diseases.
FOOTNOTES
Received 13 May 2011. Accepted 14 June 2011. ↵*Corresponding author. Mailing address: Downstate Medical Center, Departments of Neurology and Physiology/Pharmacology, Box 1213, 450 Clarkson Avenue, Brooklyn, NY 11203. Phone: (718) 270-2019. Fax: (718) 270-2459. E-mail: richard.rubenstein@downstate.edu. ↵▿ Published ahead of print on 29 June 2011.
Copyright © 2011, American Society for Microbiology. All Rights Reserved.
jvi.asm.org/content/85/17/9031.abstract Sunday, July 03, 2011
Prion Disease Detection, PMCA Kinetics, and IgG in Urine from Naturally/Experimentally Infected Scrapie Sheep and Preclinical/Clinical CWD Deer
chronic-wasting-disease.blogspot.com/2011/07/prion-disease-detection-pmca-kinetics.html Thursday, June 09, 2011
Detection of CWD prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission
chronic-wasting-disease.blogspot.com/2011/06/detection-of-cwd-prions-in-salivary.html CHRONIC WASTING DISEASE: A MODEL FOR PRION TRANSMISSION VIA SALIVA AND URINE
digitool.library.colostate.edu///exlibris/dtl/d3_1/apache_media/L2V4bGlicmlzL2R0bC9kM18xL2FwYWNoZV9tZWRpYS85NTk1OA==.pdf Sunday, December 06, 2009
Detection of Sub-Clinical CWD Infection in Conventional Test-Negative Deer Long after Oral Exposure to Urine and Feces from CWD+ Deer
snip...
Discussion Detection of subclinical infection in deer orally exposed to urine and feces (1) suggests that a prolonged subclinical state can exist, necessitating observation periods in excess of two years to detect CWD infection, and (2) illustrates the sensitive and specific application of sPMCA in the diagnosis of low-level prion infection. Based on these results, it is possible that low doses of prions, e.g. following oral exposure to urine and saliva of CWD-infected deer, bypass significant amplification in the LRS, perhaps utilizing a neural conduit between the alimentary tract and CNS, as has been demonstrated in some other prion diseases.
snip...
chronic-wasting-disease.blogspot.com/2009/12/detection-of-sub-clinical-cwd-infection.html Wednesday, March 18, 2009
Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay
chronic-wasting-disease.blogspot.com/2009/03/detection-of-cwd-prions-in-urine-and.html *** Tuesday, September 02, 2008
Detection of infectious prions in urine (Soto et al Available online 13 August 2008.)
chronic-wasting-disease.blogspot.com/2008/09/detection-of-infectious-prions-in-urine.html Subject: MAD DEER/ELK DISEASE AND POTENTIAL SOURCES
Date: Sat, 25 May 2002 18:41:46 –0700
From: "Terry S. Singeltary Sr."
Reply-To: Bovine Spongiform Encephalopathy
To: BSE-L@uni-karlsruhe.de
now, what about those 'deer scents' of 100% urine', and the prion that is found in urine, why not just pass the prion with the urine to other deer...
Mrs. Doe Pee Doe in Estrus Model FDE1 Mrs. Doe Pee's Doe in Estrus is made from Estrus urine collected at the peak of the rut, blended with Fresh Doe Urine for an extremely effective buck enticer. Use pre-rut before the does come into heat. Use during full rut when bucks are most active. Use during post-rut when bucks are still actively looking for does. 1 oz.
www.gamecalls.net/hunting...lures.html ELK SCENT/SPRAY BOTTLE
Works anytime of the year *
100 % Cow Elk-in-Heat urine (2oz.) *
Economical - mix with water in spray mist bottle *
Use wind to your advantage
Product Code WP-ESB $9.95
www.elkinc.com/Scent.asp prions in urine?
DEER & ELK URINE, LURES & SCENT CONTROL DEPARTMENT by MRS.DOE PEE'S Main Index
The Turkey Pro Sez... "Premium, fresh, top-quality, pure 100% undiluted deer lures from Mrs. Doe Pee really work. I won't trust anything else when I'm after big bucks. Sam Collora, owner of the company, proved how well his products work when he bagged this monster buck in 1996.............snip......end........CWD
www.turkeyhuntingsecrets.com/...ontroldept.htm snip...
REFERENCES
snip...see full text ;
-------- Original Message --------
Subject: DOCKET-- 03D-0186 -- FDA Issues Draft Guidance on Use of Material From Deer and Elk in Animal Feed; Availability
Date: Fri, 16 May 2003 11:47:37 -0500
From: "Terry S. Singeltary Sr."
To: fdadockets@oc.fda.gov
madcowfeed.blogspot.com/2008/07/docket-03d-0186-fda-issues-draft.html DOCKET-- 03D-0186 -- FDA Issues Draft Guidance on Use of Material From Deer and Elk in Animal Feed; Availability
Date: Fri, 16 May 2003 11:47:37 –0500
EMC 1 Terry S. Singeltary Sr. Vol #: 1
www.fda.gov/ohrms/dockets/dailys/03/Jun03/060903/060903.htm www.fda.gov/ohrms/dockets/dailys/03/oct03/100203/100203.htm PLEASE SEE FULL TEXT SUBMISSION ;
madcowfeed.blogspot.com/2008/07/docket-03d-0186-fda-issues-draft.html CWD TO HUMAN TRANSMISSION, never say never !!!
Envt.06:
Zoonotic Potential of CWD: Experimental Transmissions to Non-Human Primates
Emmanuel Comoy,1,† Valérie Durand,1 Evelyne Correia,1 Aru Balachandran,2 Jürgen Richt,3 Vincent Beringue,4 Juan-Maria Torres,5 Paul Brown,1 Bob Hills6 and Jean-Philippe Deslys1
1Atomic Energy Commission; Fontenay-aux-Roses, France; 2Canadian Food Inspection Agency; Ottawa, ON Canada; 3Kansas State University; Manhattan, KS USA; 4INRA; Jouy-en-Josas, France; 5INIA; Madrid, Spain; 6Health Canada; Ottawa, ON Canada
†Presenting author; Email: emmanuel.comoy@cea.fr
The constant increase of chronic wasting disease (CWD) incidence in North America raises a question about their zoonotic potential. A recent publication showed their transmissibility to new-world monkeys, but no transmission to old-world monkeys, which are phylogenetically closer to humans, has so far been reported. Moreover, several studies have failed to transmit CWD to transgenic mice overexpressing human PrP. Bovine spongiform encephalopathy (BSE) is the only animal prion disease for which a zoonotic potential has been proven. We described the transmission of the atypical BSE-L strain of BSE to cynomolgus monkeys, suggesting a weak cattle-to-primate species barrier. We observed the same phenomenon with a cattleadapted strain of TME (Transmissible Mink Encephalopathy). Since cattle experimentally exposed to CWD strains have also developed spongiform encephalopathies, we inoculated brain tissue from CWD-infected cattle to three cynomolgus macaques as well as to transgenic mice overexpressing bovine or human PrP. Since CWD prion strains are highly lymphotropic, suggesting an adaptation of these agents after peripheral exposure, a parallel set of four monkeys was inoculated with CWD-infected cervid brains using the oral route. Nearly four years post-exposure, monkeys exposed to CWD-related prion strains remain asymptomatic. In contrast, bovinized and humanized transgenic mice showed signs of infection, suggesting that CWD-related prion strains may be capable of crossing the cattle-to-primate species barrier. Comparisons with transmission results and incubation periods obtained after exposure to other cattle prion strains (c-BSE, BSE-L, BSE-H and cattle-adapted TME) will also be presented, in order to evaluate the respective risks of each strain.
Envt.07:
Pathological Prion Protein (PrPTSE) in Skeletal Muscles of Farmed and Free Ranging White-Tailed Deer Infected with Chronic Wasting Disease
Martin L. Daus,1,† Johanna Breyer,2 Katjs Wagenfuehr,1 Wiebke Wemheuer,2 Achim Thomzig,1 Walter Schulz-Schaeffer2 and Michael Beekes1 1Robert Koch Institut; P24 TSE; Berlin, Germany; 2Department of Neuropathology, Prion and Dementia Research Unit, University Medical Center Göttingen; Göttingen, Germany
†Presenting author; Email: dausm@rki.de
Chronic wasting disease (CWD) is a contagious, rapidly spreading transmissible spongiform encephalopathy (TSE) occurring in cervids in North America. Despite efficient horizontal transmission of CWD among cervids natural transmission of the disease to other species has not yet been observed. Here, we report a direct biochemical demonstration of pathological prion protein PrPTSE and of PrPTSE-associated seeding activity in skeletal muscles of CWD-infected cervids. The presence of PrPTSE was detected by Western- and postfixed frozen tissue blotting, while the seeding activity of PrPTSE was revealed by protein misfolding cyclic amplification (PMCA). The concentration of PrPTSE in skeletal muscles of CWD-infected WTD was estimated to be approximately 2000- to 10000-fold lower than in brain tissue. Tissue-blot-analyses revealed that PrPTSE was located in muscle- associated nerve fascicles but not, in detectable amounts, in myocytes. The presence and seeding activity of PrPTSE in skeletal muscle from CWD-infected cervids suggests prevention of such tissue in the human diet as a precautionary measure for food safety, pending on further clarification of whether CWD may be transmissible to humans.
www.landesbioscience.com/journals/prion/Prion5-Supp-PrionEnvironment.pdf?nocache=1333529975 PLUS, THE CDC DID NOT PUT THIS WARNING OUT FOR THE WELL BEING OF THE DEER AND ELK ;
Thursday, May 26, 2011
Travel History, Hunting, and Venison Consumption Related to Prion Disease Exposure, 2006-2007 FoodNet Population Survey
Journal of the American Dietetic Association Volume 111, Issue 6 , Pages 858-863, June 2011.
transmissiblespongiformencephalopathy.blogspot.com/2011/05/travel-history-hunting-and-venison.html NOR IS THE FDA recalling this CWD positive elk meat for the well being of the dead elk ;
Wednesday, March 18, 2009
Noah's Ark Holding, LLC, Dawson, MN RECALL Elk products contain meat derived from an elk confirmed to have CWD NV, CA, TX, CO, NY, UT, FL, OK RECALLS AND FIELD CORRECTIONS: FOODS CLASS II
chronic-wasting-disease.blogspot.com/2009/03/noahs-ark-holding-llc-dawson-mn-recall.html Sunday, January 22, 2012
Chronic Wasting Disease CWD cervids interspecies transmission
chronic-wasting-disease.blogspot.com/2012/01/chronic-wasting-disease-cwd-cervids.html now, let’s see what the authors said about this casual link, personal communications years ago. see where it is stated NO STRONG evidence. so, does this mean there IS casual evidence
?
“Our conclusion stating that we found no strong evidence of CWD transmission to humans”
From: TSS (216-119-163-189.ipset45.wt.net)
Subject: CWD aka MAD DEER/ELK TO HUMANS
Date: September 30, 2002 at 7:06 am PST
From: "Belay, Ermias"
To:
Cc: "Race, Richard (NIH)" ; ; "Belay, Ermias"
Sent: Monday, September 30, 2002 9:22 AM
Subject: RE: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Dear Sir/Madam,
In the Archives of Neurology you quoted (the abstract of which was attached to your email), we did not say CWD in humans will present like variant CJD.
That assumption would be wrong. I encourage you to read the whole article and call me if you have questions or need more clarification (phone: 404-639-3091). Also, we do not claim that "no-one has ever been infected with prion disease from eating venison." Our conclusion stating that we found no strong evidence of CWD transmission to humans in the article you quoted or in any other forum is limited to the patients we investigated.
Ermias Belay, M.D. Centers for Disease Control and Prevention
-----Original Message-----
From:
Sent: Sunday, September 29, 2002 10:15 AM
To: rr26k@nih.gov; rrace@niaid.nih.gov; ebb8@CDC.GOV
Subject: TO CDC AND NIH - PUB MED- 3 MORE DEATHS - CWD - YOUNG HUNTERS
Sunday, November 10, 2002 6:26 PM ......snip........end..............TSS
Thursday, April 03, 2008
A prion disease of cervids: Chronic wasting disease
2008 1: Vet Res. 2008 Apr 3;39(4):41
A prion disease of cervids: Chronic wasting disease
Sigurdson CJ.
snip...
*** twenty-seven CJD patients who regularly consumed venison were reported to the Surveillance Center***,
snip...
full text ;
chronic-wasting-disease.blogspot.com/2008/04/prion-disease-of-cervids-chronic.html Sunday, January 22, 2012
Chronic Wasting Disease CWD cervids interspecies transmission
chronic-wasting-disease.blogspot.com/2012/01/chronic-wasting-disease-cwd-cervids.html sorry about getting long winded...
kind regards,
terry
